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ALAS1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1081.84 DKK - 3058.99 DKK

Specifications

Antigen ALAS1
Concentration 0.27 mg/mL
Applications Immunofluorescence, Immunocytochemistry, Western Blot, Immunoprecipitation
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16815744
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Proteintech
16200-1-AP-20UL
20 μL
1081.84 DKK
20µL
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16805744
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Proteintech
16200-1-AP-150UL
150 μL
3058.99 DKK
150µL
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Description

Description

ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5′ phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.
Specifications

Specifications

ALAS1
Immunofluorescence, Immunocytochemistry, Western Blot, Immunoprecipitation
Unconjugated
Rabbit
Mouse, Rat, Human
P13195, P13196, Q8VC19
11655, 211, 65155
ALAS1 Fusion Protein Ag9126
Primary
-20°C
ALAS1
0.27 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
ALAS, ALAS H, ALAS1, ALAS3, ALASH, Delta ALA synthase 1, MIG4
Alas1
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documents

Documents

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