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MCU/CCDC109A Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1081.84 DKK - 3058.99 DKK

Specifications

Antigen MCU/CCDC109A
Concentration 0.35 mg/mL
Applications Immunofluorescence, Immunocytochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16804825
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Proteintech
26312-1-AP-20UL
20 μL
1081.84 DKK
20µL
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16894815
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Proteintech
26312-1-AP-150UL
150 μL
3058.99 DKK
150µL
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Description

Description

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a ′fight-or-flight′ response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.
Specifications

Specifications

MCU/CCDC109A
Immunofluorescence, Immunocytochemistry, Western Blot
Unconjugated
Rabbit
Human
Q8NE86
90550
MCU/CCDC109A Fusion Protein Ag24733
Primary
-20°C
MCU
0.35 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
C10orf42, Calcium uniporter protein, CCDC109A, MCU
MCU
IgG
Antigen Affinity Chromatography
Antibody
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SDS
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Documents

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