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MMP2 Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

1081.84 DKK - 3058.99 DKK

Specifications

Antigen MMP2
Concentration 0.25 mg/mL
Applications Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Western Blot
Classification Polyclonal
Conjugate Unconjugated
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
16806723
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Proteintech
10373-2-AP-20UL
20 μL
1081.84 DKK
20µL
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16896713
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Proteintech
10373-2-AP-150UL
150 μL
3058.99 DKK
150µL
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Description

Description

MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
Specifications

Specifications

MMP2
Immunoprecipitation, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Western Blot
Unconjugated
Rabbit
Zebrafish, Mouse, Human, Rat
P08253, P33434, P33436
17390, 337179, 4313, 81686
MMP2 Fusion Protein Ag0549
Primary
-20°C
MMP2
0.25 mg/mL
Polyclonal
Liquid
RUO
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
72 kDa gelatinase, 72 kDa type IV collagenase, CLG4, CLG4A, Gelatinase A, Matrix metalloproteinase 2, MMP 2, MMP II, MMP2, MONA, TBE 1
mmp2
IgG
Antigen Affinity Chromatography
Antibody
Videos
SDS
Documents

Documents

Certificates
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