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NEDD4 Rabbit anti-Human, Mouse, Non-human primate, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marca: Proteintech 21698-1-AP-20UL
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Descripción
This antibody can recognize NEDD4-1 and NEDD4-2.
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein. It contains one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It is involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. It acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, a paradigm analogous to that of Mdm2 and p53. It is also reported to be involved in the budding of many viruses and is the regulator of epithelial Na+ channels, which lead to arterial hypertension. NEDD4 protein is localized to the sarcolemmal region of muscle fibers. Increase in NEDD4 protein expression leads to unloaded and denervated muscles as well as a decrease in Notch1 expression. Hence it acts as down regulator of Notch-1 gene expression.Especificaciones
| NEDD4 | |
| Polyclonal | |
| Unconjugated | |
| NEDD4 | |
| KIAA0093, NEDD 4, NEDD4, NEDD4 1, RPF1 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 17999, 25489, 4734 | |
| -20°C | |
| Liquid |
| Immunoprecipitation, Western Blot, Immunohistochemistry (Paraffin) | |
| 0.22 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| P46934, P46935, Q62940 | |
| Nedd4 | |
| NEDD4 Fusion Protein Ag16291 | |
| 20 μL | |
| Primary | |
| Mouse, Rat, Human, Non-human Primate | |
| Antibody | |
| IgG |
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