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PD-L1/CD274 Mouse anti-Human, Mouse, Porcine, Rat, Clone: 2B11D11, Proteintech
Mouse Monoclonal Antibody
Marca: Proteintech 66248-1-IG-150UL
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Descripción
PD-L1 (Programmed death receptor ligand 1, B7-H1, CD274) is a 40 kDa transmembrane protein and B7 family member. PD-L1 has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production, and PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion. Together with B7.1, PD-L1 can inactivate T cells and this relationship is a focal point of cancer therapeutic treatment. At least two isoforms of PDL-1 are known to exist.Especificaciones
| PD-L1/CD274 | |
| Monoclonal | |
| 1.55 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q9EP73, Q9NZQ7 | |
| CD274 | |
| PD-L1/CD274 Fusion Protein Ag12443 | |
| 150 μL | |
| Primary | |
| Human, Mouse, Pig, Rat | |
| Antibody | |
| IgG1 |
| Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot | |
| 2B11D11 | |
| Unconjugated | |
| CD274 | |
| B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, PD-L1, PD-L1/CD274, Programmed death ligand 1 | |
| Mouse | |
| Protein G | |
| RUO | |
| 29126, 499342, 574058, 60533 | |
| -20°C | |
| Liquid |
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