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RAD18 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marca: Proteintech 18333-1-AP-20UL
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Descripción
This antibody is specific to RAD18.
Human Rad18 (hRad18) is homologue of the S. pombe Rad18. In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast. In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif. It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18. This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6. The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa. The human Rad18 is ubiquitously expressed in various human tissues.Especificaciones
| RAD18 | |
| Polyclonal | |
| Unconjugated | |
| RAD18 | |
| hHR18, hRAD18, RAD18, RAD18 homolog (S. cerevisiae), RING finger protein 73, RNF73 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 362412, 56852, 58186 | |
| -20°C | |
| Liquid |
| Western Blot | |
| 0.3 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q9NS91, Q9QXK2 | |
| Rad18 | |
| RAD18 Fusion Protein Ag12944 | |
| 20 μL | |
| Primary | |
| Rat, Human, Mouse | |
| Antibody | |
| IgG |
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