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ACTN4 Mouse anti-Human, Mouse, Rat, Clone: 1E12B8, Proteintech
Mouse Monoclonal Antibody
Brand: Proteintech 66628-1-IG-150UL
This item is not returnable.
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Description
This antibody recognizes 105 kDa of endogenous ACTN4 protein in various lysates.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.Specifications
| ACTN4 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
| O43707, P57780, Q9QXQ0 | |
| Actn4 | |
| ACTN4 Fusion Protein Ag13549 | |
| 150 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG1 |
| Immunohistochemistry (Paraffin), Western Blot | |
| 1E12B8 | |
| Unconjugated | |
| ACTN4 | |
| ACTININ 4, actinin, alpha 4, ACTN4, Alpha actinin 4, F actin cross linking protein, FSGS, FSGS1, Non muscle alpha actinin 4 | |
| Mouse | |
| Protein G | |
| RUO | |
| 60595, 63836, 81 | |
| -20°C | |
| Liquid |
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